She won the National Film Award for Best Actress for portraying actress Savitri in the Telugu film Mahanati (2018)
Keerthy is the daughter of Malayalam film producer G. Suresh Kumar and actress Menaka. Keerthy began her career as a child actress in the early 2000s and returned to films after studying fashion design
She had her first lead role in the 2013 Malayalam film Geethaanjali. She went on to star in successful films such as Ring Master (2014), Idhu Enna Maayam (2015), Nenu Sailaja (2016), Remo (2016), Bairavaa (2017), Nenu Local (2017), Thaana Serndha Kootam (2018), Mahanati (2018), Sarkar (2018), Saani Kaayidham (2022) and Sarkaru Vaari Paata (2022).
Movie Award for Best Female Debutant and the Asianet Film Award for Best New Face of the Year for her performance in Geethaanjali