Andy Murray knocked out by John Isner despite late fightback
Murray had won all eight of his previous battles with 20th-seeded American John Isner.
Two-time champion Andy Murray suffered his earliest ever exit from Wimbledon as he was beaten 6-4, 7-6 (4) 6-7 (3), 6-4 by an inspired John Isner in the second round on Wednesday
Murray had won all eight of his previous battles with the 6ft 10in Isner but in their first clash on grass, the 20th-seeded American served brilliantly to clinch a superb victory.
The 37-year-old Isner hit 82 winners, including 36 aces, won 43 points of 61 at the net, and took both of his two break points.
Murray, 35, who did not play competitively for two weeks coming into Wimbledon due to an abdominal injury, dropped his serve in the third game.
Isner took the second-set tiebreak 7-4 but Murray hit back to win the third set on the tiebreak, 7-3.
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